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Definition: |
Nystatin is a substance, or a mixture of two or more
substances, produced by the growth of Streptomyces
noursei Brown et al. (Fam. Streptomycetaceae). 4400
potency/mg min |
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Appearance: |
Yellow to light tan powder, having an odor
suggestive of cereals. Is hygroscopic, and is affected
by long exposure to light, heat, and air. |
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Solubility: |
Slightly to sparingly soluble in methanol, in n-propyl
alcohol, and in n-butyl alcohol; practically insoluble
in water and in alcohol; insoluble in chloroform, in
ether, and in benzene. |
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Identification: |
Ultraviolet Absorption . |
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Ratio: |
the ratio (A 230/A 279(sh)) is between 0.90--- 1.25 |
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pH: |
6.0 --8.0, in 3% aqueous suspension. |
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Loss on drying: |
5.0% max |
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Assay: |
4400 potency/mg min |
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Particle size: |
100% Should be less than 25¦Ìm .
More than 65% Should be less than 10 ¦Ìm .
More than 85% Should be less than 15 ¦Ìm . |
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Storage : |
Preserve in tight, light-resistant containers. |
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Packing: |
in 25kgs net/carton |
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